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Sleep deprivation: Changes of monoamines and acetylcholine in rat brain

1969; Elsevier BV; Volume: 8; Issue: 15 Linguagem: Inglês

10.1016/0024-3205(69)90143-x

1879-0631

Kyoichiro Tsuchiya, Michio Toru, Toyoharu Kobayashi,

Biochemical effects in animals

Total sleep deprivation in rats produced by maintenance on a 24-hour avoidance schedule produced slightly increased acetylcholine in the telencephalon and markedly decreased 5-hydroxytryptamine and norepinephrine in the diencephalon. After a short period of sleep following the 24-hour sleep deprivation, the decreased 5-hydroxytryptamine and norepinephrine levels rapidly equalled or surpassed the control levels. When the paradoxical sleep was deprived for 96 hours, the acetylcholine content decreased in the telencephalon and the norepinephrine level was significantly lowered in the brain stem. There was, however, no significant change in the level of 5-hydroxytryptamine after 96 hours of paradoxical sleep deprivation.