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INHIBITION OF EJACULATION BY CHLORPROMAZINE

1971; Lippincott Williams & Wilkins; Volume: 152; Issue: 5 Linguagem: Inglês

10.1097/00005053-197105000-00008

1539-736X

Harvey Roy Greenberg,

Phenothiazines and Benzothiazines Synthesis and Activities

Various disturbances of sexual activity can occur in men undergoing phenothiazine therapy, including diminished libido, erectile impotence, and ejaculatory inhibition. The latter side effect has been encountered during treatment with thioridazine (Mellaril) and much more rarely with chlorprothixene (Taractan). In this report, ejaculatory inhibition caused by chlorpromazine (Thorazine) is described for the first time. The patient developed varying degrees of erectile impotence, decrease in libido, and ejaculatory inhibition. At doses of 1200 mg/day he was totally impotent. At 400 mg/day, libido and erectile potency returned, orgasm occurred, but ejaculatory inhibition persisted. The symptom became a source of considerable intrapsychic distress, along with the other Thorazine-induced sexual problems, which also caused disruption in the patient's marriage. All sexual difficulties abated upon switching to another phenothiazine. The etiology of ejaculatory inhibition with phenothiazine therapy is unclear. It is fortunately rare, but since it is a source of anxiety to fragile borderline or psychotic patients, the therapist should exercise extreme vigilance for its appearance with any phenothiazine.