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An imidazole alkaloid and other constituents from Pilocarpus trachyllophus

1996; Elsevier BV; Volume: 42; Issue: 3 Linguagem: Inglês

10.1016/0031-9422(95)00852-7

1873-3700

Manoel Andrade‐Neto, Paulo Henriques Mendes, Edilberto R. Silveira,

Chemical synthesis and alkaloids

Roots of Pilocarpus trachyllophus yielded (−)-episesamin, hesperidin, tridecan-2-one, 1-hydroxytridecan-2-one, N-isobutyl-deca-2(E),4(E)-dienamide, pilocarpine and a new imidazole alkaloid, 13-nor-7(11)-dehydropilocarpine. Except for pilocarpine and tridecan-2-one, this is the first report of these substances in the genus Pilocarpus. Structural determinations were accomplished by spectroscopic analysis, particularly two-dimensional NMR, chemical interconversion and, where appropriate, comparison with literature data.