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Lipid peroxidation in cord blood at birth

1996; Elsevier BV; Volume: 174; Issue: 1 Linguagem: Inglês

10.1016/s0002-9378(96)70374-5

1097-6868

Wei Wang, Calvin C P Pang, Michael S. Rogers, A.M.Z. Chang,

Metabolism and Genetic Disorders

The purpose of this study was to determine oxygen free radical activity in the neonate at birth and relate it to umbilical cord blood acid-base status.A series of 110 singleton deliveries had determination of two lipoperoxides in umbilical cord blood: malondialdehyde and organic hydroperoxide. Umbilical pH, PO2, PCO2, bicarbonate, and base excess were also measured.There was a significant association between lipoperoxides and cord blood pH and base excess. A significant difference existed in the levels of umbilical artery lipoperoxides between nonacidemic and acidemic fetus, as defined by an umbilical arterial pH < 7.20.There is a positive association between lipoperoxide production and acid-base balance at delivery.