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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Dengue Virus Inhibits the Production of Type I Interferon in Primary Human Dendritic Cells

2010; American Society for Microbiology; Volume: 84; Issue: 9 Linguagem: Inglês

10.1128/jvi.02514-09

ISSN

1098-5514

Autores

Juan R. Rodríguez-Madoz, Dabeiba Bernal‐Rubio, Dorota Kaminski, K. L. Boyd, Ana Fernandez‐Sesma,

Tópico(s)

Viral Infections and Outbreaks Research

Resumo

Dengue virus (DENV) infects human immune cells in vitro and likely infects dendritic cells (DCs) in vivo. DENV-2 productive infection induces activation and release of high levels of chemokines and proinflammatory cytokines in monocyte-derived DCs (moDCs), with the notable exception of alpha/beta interferon (IFN-alpha/beta). Interestingly, DENV-2-infected moDCs fail to prime T cells, most likely due to the lack of IFN-alpha/beta released by moDCs, since this effect was reversed by addition of exogenous IFN-beta. Together, our data show that inhibition of IFN-alpha/beta production by DENV in primary human moDCs is a novel mechanism of immune evasion.

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