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Clastogenic and Anticlastogenic Effect of the Essential Oil from Casearia sylvestris Swart.

2007; Taylor & Francis; Volume: 19; Issue: 4 Linguagem: Inglês

10.1080/10412905.2007.9699309

2163-8152

Fabrício G. Sousa, Naira Fernanda Zanchett Schneider, Caroline Eliza Mendes, Neusa Fernandes de Moura, Rosiane Berenice Nicoloso Denardin, Renata Matuo, Mário Sérgio Mantovani,

Plant-Derived Bioactive Compounds

Abstract The essential oil composition obtained from the leaves of Casearia sylvestris has been investigated by GC and GC/MS. Thirty-seven compounds were identified in the oil. The major constituents of which were β-caryophyllene (27.5%) and bicyclogermacrene (24.2%). The clastogenic and anticlastogenic effect of the oil was tested by chromosome aberration in cells of tissue hepatoma of Rattus novergicus. The three different concentrations of C. sylvestris oil showed clastogenic effects. However, in the tests of anticlastogenicity, the same three concentrations showed protective activity when associated with ethyl methanesulfonate (EMS).