minidiscs encodes a putative amino acid transporter subunit required non-autonomously for imaginal cell proliferation

2000; Elsevier BV; Volume: 92; Issue: 2 Linguagem: Inglês

10.1016/s0925-4773(99)00338-x

ISSN

1872-6356

Autores

Jennifer F Martin, Evelyn Hersperger, Amanda Simcox, Allen Shearn,

Tópico(s)

Neurobiology and Insect Physiology Research

Resumo

Drosophila minidiscs mutant larvae have smaller imaginal discs than wild-type larvae. However, transplantation experiments have revealed that minidiscs mutant imaginal discs can grow if cultured in non-mutant hosts. These data suggest that minidiscs is required in one or more non-imaginal tissues for synthesis and/or secretion of a diffusible factor that stimulates imaginal cell proliferation. The 2.3 kb minidiscs transcript accumulates in the larval fat body and encodes a protein containing 12 putative membrane spanning domains that is similar in sequence to amino acid transporter subunits from other eukaryotes, including humans. We propose that in response to amino acid uptake by the transporter encoded by minidiscs, the fat body secretes a diffusible factor required for imaginal disc proliferation.

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