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A cryptic plasmid from Nocardia orientalis NRRL 2452, a vancomycin producer.

1986; Springer Nature; Volume: 39; Issue: 5 Linguagem: Inglês

10.7164/antibiotics.39.694

1881-1469

Yong Kyun Oh, Louis R. Fare, Dean P. Taylor, Jenifer Widger, L. J. NISBET,

Microbial Natural Products and Biosynthesis

A plasmid was found in Nocardia orientalis (formerly Streptonryces orientalis). Physical characterization of the plasmid DNA indicates a size of 33.5 kb and a single cleavage site for EcoR I. The presence of plasmid, and variation in its copy member, did not directly affect vancomycin resistance or production levels. The plasmid represents the first to be isolated and characterized from a glycopeptide-producing nocardia.