Portal de Periódicos da CAPES

Evidence for Interference With the Intestinal Absorption of Levothyroxine Sodium by Aluminum Hydroxide

1992; American Medical Association; Volume: 152; Issue: 1 Linguagem: Inglês

10.1001/archinte.1992.00400130181024

1538-3679

Ami D. Sperber,

Neuroendocrine Tumor Research Advances

A patient with hypothyroidism who was euthyroid on a fixed-dosage, long-term maintenance regimen of levothyroxine sodium developed persistently elevated serum thyrotropin levels while receiving an aluminum hydroxide— containing antacid. The thyrotropin levels returned to normal shortly after cessation of the antacid therapy. These observations indicate that aluminum hydroxide may interfere with the bioavailability of thyroxine. The thyroid function of patients who are receiving replacement or suppressive thyroxine therapy should be monitored following the commencement of concurrent treatment with medications containing aluminum hydroxide. ( Arch Intern Med. 1992;152:183-184)