Produção Nacional
Revisado por pares
Performance of 3 Methods for Quality Control for Gynecologic Cytology Diagnoses
2008; Karger Publishers; Volume: 52; Issue: 4 Linguagem: Inglês
10.1159/000325549
ISSN1938-2650
AutoresMaria Lúcia Utagawa, Neuza Kasumi Shirata, Maria da Gloria Mattosinho de Castro Ferraz, Celso di Loreto, Miria Dall’ Agnol, Adhemar Longatto‐Filho,
Tópico(s)AI in cancer detection
ResumoTo evaluate performance and viability of internal quality control (QC) strategies in a public health laboratory of the state of São Paulo. Study DesignA retrospective study was performed with 3 QC strategies to improve internal cytologic diagnoses: morphologic guidedlist criteria (MGLC), 100% rapid-rescreening (100% RR) of negative slides ("turret" method) and 10% rescreening (10% R) of negative slides.Cases were examined at Adolfo Lutz Institute, São Paulo, Brazil, from 2002 to 2004.Histopathologic results, when available, were considered gold standard; cytologic consensus diagnosis was by 2 pathologists when histologic results were unavailable. ResultsMGLC selected 20.7% samples with cytologic atypias, 10% R selected 0.6% and RR selected 2.5%.Cytologic/histologic initial concordance was 57.4%, low-grade squamous intraepithelial lesion false negative rate was 34.9% and high-grade squamous intraepithelial lesion false negative rate was 12.2%.After diagnosis, consensus concordance was 97.2%. ConclusionThe 100% RR and 10% R QC strategies detected more false negative cases in liquidbased cytology than in conventional Pap smears.The 100% RR strategy reduced the false negative results and allowed evaluation of individual staff performance.The 10% R strategy did not offer significant results.We concluded that association of MGLC and 100% RR strategies might improve cytologic diagnostic quality.
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