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Synthesis and characterization of PVP-coated large core iron oxide nanoparticles as an MRI contrast agent

2008; IOP Publishing; Volume: 19; Issue: 16 Linguagem: Inglês

10.1088/0957-4484/19/16/165101

1361-6528

Ha‐Young Lee, Sang‐Hoon Lee, Chenjie Xu, Jin Xie, Jin-Hyung Lee, Bing Wu, Ai Leen Koh, Xiaoying Wang, Robert Sinclair, Shan X. Wang, Dwight G. Nishimura, Sandip Biswal, Shouheng Sun, Sun Hang Cho, Xiaohong Chen,

Characterization and Applications of Magnetic Nanoparticles

The purpose of this study was to synthesize biocompatible polyvinylpyrrolidone (PVP)-coated iron oxide (PVP-IO) nanoparticles and to evaluate their efficacy as a magnetic resonance imaging (MRI) contrast agent. The PVP-IO nanoparticles were synthesized by a thermal decomposition method and characterized by x-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), and a superconducting quantum interface device (SQUID). The core size of the particles is about 8–10 nm and the overall size is around 20–30 nm. The measured r2 (reciprocal of T2 relaxation time) and r2* (reciprocal of T2* relaxation time) are 141.2 and 338.1 (s mM)−1, respectively. The particles are highly soluble and stable in various buffers and in serum. The macrophage uptake of PVP-IO is comparable to that of Feridex as measured by a Prussian blue iron stain and phantom study. The signal intensity of a rabbit liver was effectively reduced after intravenous administration of PVP-IO. Therefore PVP-IO nanoparticles are potentially useful for T2-weighted MR imaging.