Sulfation of a polysaccharide obtained from Phellinus ribis and potential biological activities of the sulfated derivatives
2009; Elsevier BV; Volume: 77; Issue: 2 Linguagem: Inglês
10.1016/j.carbpol.2009.01.008
ISSN1879-1344
AutoresYuhong Liu, Chunhui Liu, Haining Tan, Ting Zhao, Jichao Cao, Fengshan Wang,
Tópico(s)Polysaccharides and Plant Cell Walls
ResumoThe paper reports the preparation, characterization and potential biological activities of a chemically sulfated polysaccharide isolated from Phellinus ribis. Four sulfated derivatives (PRP-SI–IV) with variable degrees of substitution were obtained by the chlorosulfonic acid method, without degradation of the polysaccharide (PRP). The sulfate groups were not regularly distributed along the polysaccharide chain with a multiple substitution pattern as determined by 13C NMR. The sulfated derivatives except for PRP-SI showed significant inhibition effects on HepG2 cells in comparison with the native non-sulfated polysaccharide (PRP). All sulfated derivatives could block new angiogenic vessel formation in zebrafish assay, however, the effects were less than PRP.
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