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Egr-1 negatively regulates expression of the sodium?calcium exchanger-1 in cardiomyocytes in vitro and in vivo

2004; Oxford University Press; Volume: 65; Issue: 1 Linguagem: Inglês

10.1016/j.cardiores.2004.09.026

1755-3245

Chunhui Wang, Stevan Dostanic, Nicolas Servant, Lorraine E. Chalifour,

Cardiac electrophysiology and arrhythmias

Objective: Increased expression of the transcription factor early growth response gene-1 (Egr-1) accompanies catecholamine infusion. Catecholamine-treated, Egr-1-deficient (−/−) mice show exacerbated cardiac damage when compared to similarly treated wild-type (+/+) mice, suggesting that Egr-1 reduces heart damage. We sought to identify Egr-1-mediated cardiac sparing genes.