Portal de Periódicos da CAPES

Erectile Function Outcome Reporting After Clinically Localized Prostate Cancer Treatment

2007; Lippincott Williams & Wilkins; Volume: 178; Issue: 2 Linguagem: Inglês

10.1016/j.juro.2007.03.140

1527-3792

Arthur L. Burnett, Gunnar Aus, Edith Canby‐Hagino, Michael S. Cookson, Anthony V. D’Amico, Roger R. Dmochowski, David T. Eton, Jeffrey D. Forman, S. Larry Goldenberg, Javier Hernández, Celestia S. Higano, Stephen R. Kraus, Monica Liebert, Judd W. Moul, Catherine M. Tangen, J. Brantley Thrasher, Ian M. Thompson,

Genital Health and Disease

No AccessJournal of UrologyAdult urology1 Aug 2007Erectile Function Outcome Reporting After Clinically Localized Prostate Cancer Treatment Arthur L. Burnett, Gunnar Aus, Edith D. Canby-Hagino, Michael S. Cookson, Anthony V. D'Amico, Roger R. Dmochowski, David T. Eton, Jeffrey D. Forman, S. Larry Goldenberg, Javier Hernandez, Celestia S. Higano, Stephen Kraus, Monica Liebert, Judd W. Moul, Catherine Tangen, J. Brantley Thrasher, Ian Thompson, and American Urological Association Prostate Cancer Guideline Update Panel Arthur L. BurnettArthur L. Burnett , Gunnar AusGunnar Aus , Edith D. Canby-HaginoEdith D. Canby-Hagino , Michael S. CooksonMichael S. Cookson , Anthony V. D'AmicoAnthony V. D'Amico , Roger R. DmochowskiRoger R. Dmochowski , David T. EtonDavid T. Eton , Jeffrey D. FormanJeffrey D. Forman , S. Larry GoldenbergS. Larry Goldenberg , Javier HernandezJavier Hernandez , Celestia S. HiganoCelestia S. Higano , Stephen KrausStephen Kraus , Monica LiebertMonica Liebert , Judd W. MoulJudd W. Moul , Catherine TangenCatherine Tangen , J. Brantley ThrasherJ. Brantley Thrasher , Ian ThompsonIan Thompson , and American Urological Association Prostate Cancer Guideline Update Panel View All Author Informationhttps://doi.org/10.1016/j.juro.2007.03.140AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: In conjunction with the assignment to update the Guidelines for Management of Clinically Localized Prostate Cancer, the American Urological Association Prostate Cancer Guideline Update Panel performed a side analysis of the reporting of erectile function outcomes in this clinical context as published in the medical literature. Materials and Methods: Four National Library of Medicine PubMed® Services literature searches targeting articles published from 1991 through early 2004 were done to derive outcome reporting (efficacy or side effects) for the treatment of clinical stage T1 or T2 N0M0 prostate cancer. A database was constructed containing descriptions relating to erectile function as well as numerical frequency rates of complete erectile dysfunction, and partial and intact erectile function for various treatments. A literature review was also done, consisting of a PubMed Services search of current measures and protocols used for assessing erectile function outcomes and a survey of consensus opinion sources on the management of male sexual dysfunctions. Results: Based on inclusion criteria 436 articles were selected. Of these articles database extraction from 100 pertaining to radical prostatectomy garnered various characterizations of erectile function, including qualitative descriptions, generic terminology and rating systems. Database extraction from 31 articles, in which results for at least 50 patients were reported, yielded ranges of rates for complete erectile dysfunction, partial erectile function and intact erectile function that were 26% to 100%, 16% to 48% and 9% to 86% for radical prostatectomy, 8% to 85%, 21% to 47% and 36% to 63% for external beam radiation, and 14% to 61%, 21% and 18% for interstitial radiation, respectively. The literature review showed an evolution in standards for studying and reporting erectile function outcomes. Conclusions: Clinical studies reporting erectile function outcomes after localized prostate cancer treatment often demonstrate poorly interpretable and inconsistent manners of assessment as well as widely disparate rates of erectile dysfunction and erectile function. Future studies must apply scientifically rigorous methodology and standard outcomes measures to advance this field of study. References 1 : Erectile dysfunction following radical prostatectomy. JAMA2005; 293: 2648. Google Scholar 2 : Prostate Cancer Clinical Guidelines Panel Summary report on the management of clinically localized prostate cancer. J Urol1995; 154: 2144. Link, Google Scholar 3 : NIH Consensus Conference: Impotence. JAMA1993; 270: 83. Google Scholar 4 : Sexual function following radical prostatectomy: influence of preservation of neurovascular bundles. J Urol1991; 145: 998. Link, Google Scholar 5 : Potency, continence and complication rates in 1,870 consecutive radical retropubic prostatectomies. J Urol1999; 162: 433. Link, Google Scholar 6 : Factors predicting recovery of erections after radical prostatectomy. J Urol2000; 164: 1929. Link, Google Scholar 7 : The RAND 36-item health survey 1.0. Health Econ1993; 2: 217. Crossref, Medline, Google Scholar 8 : Recovery of health related quality of life in the year after radical prostatectomy: early experience. J Urol1999; 161: 515. Link, Google Scholar 9 : Development and validation of the expanded prostate cancer index composite (EPIC) for comprehensive assessment of health-related quality of life in men with prostate cancer. Urology2000; 56: 899. Crossref, Medline, Google Scholar 10 : The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology1997; 49: 822. Crossref, Medline, Google Scholar 11 : Standards for clinical trials in male sexual dysfunction: erectile dysfunction and rapid ejaculation. In: Sexual Medicine: Sexual Dysfunctions in Men and Women. Edited by . Paris: Health Publications2004: 223. chapt 8. Google Scholar 12 : Patient-reported urinary continence and sexual function after anatomic radical prostatectomy. Urology2000; 55: 58. Google Scholar 13 : Determinants of long-term quality of life and voiding function of patients treated with radical prostatectomy or permanent brachytherapy for prostate cancer. BJU Int2004; 94: 1003. Google Scholar 14 : Comparative quality-of-life analysis after radical prostatectomy or external beam radiation for localized prostate cancer. Urology1999; 54: 509. Google Scholar 15 : Quality-of-life outcomes in men treated for localized prostate cancer. JAMA1995; 273: 129. Crossref, Medline, Google Scholar 16 : Comprehensive comparison of health-related quality of life after contemporary therapies for localized prostate cancer. J Clin Oncol2002; 20: 557. Google Scholar 17 : Health related quality of life in men with prostate cancer. J Urol2003; 169: 1653. Link, Google Scholar 18 : Recommendations of the 1st International Consultation on Erectile Dysfunction. In: Erectile Dysfunction. Edited by . Plymouth, United Kingdom: Health Publications1999: 709. Google Scholar 19 : Summary of the recommendations on sexual dysfunctions in men. In: Sexual Medicine: Sexual Dysfunctions in Men and Women. Edited by . Paris: Health Publications2004: 605. chapt 17. Google Scholar 20 : The International Index of Erectile Function (IIEF): a state-of-the-science review. Int J Impot Res2002; 14: 226. Google Scholar 21 : EDITS: development of questionnaires for evaluating satisfaction with treatments for erectile dysfunction. Urology1999; 53: 793. Google Scholar 22 : Treatment responsiveness of the Self-Esteem and Relationship questionnaire in erectile dysfunction. Urology2003; 61: 888. Google Scholar 23 : The psychological and interpersonal relationship scales: assessing psychological and relationship outcomes associated with erectile dysfunction and its treatment. Arch Sex Behav2004; 33: 19. Google Scholar © 2007 by American Urological AssociationFiguresReferencesRelatedDetailsCited byBerge V, Dickinson L, McCartan N, Hindley R, Diep L, Emberton M and Ahmed H (2013) Morbidity Associated with Primary High Intensity Focused Ultrasound and Redo High Intensity Focused Ultrasound for Localized Prostate CancerJournal of Urology, VOL. 191, NO. 6, (1764-1769), Online publication date: 1-Jun-2014.Bernstein A, Levinson A, Hobbs A, Lavery H and Samadi D (2012) Validation of Online Administration of the Sexual Health Inventory for MenJournal of Urology, VOL. 189, NO. 4, (1456-1461), Online publication date: 1-Apr-2013.Gratzke C, Strong T, Gebska M, Champion H, Stief C, Burnett A and Bivalacqua T (2010) Activated RhoA/Rho Kinase Impairs Erectile Function After Cavernous Nerve Injury in RatsJournal of Urology, VOL. 184, NO. 5, (2197-2204), Online publication date: 1-Nov-2010.Dahl D, Barry M, McGovern F, Chang Y, Walker-Corkery E and McDougal W (2009) A Prospective Study of Symptom Distress and Return to Baseline Function After Open Versus Laparoscopic Radical ProstatectomyJournal of Urology, VOL. 182, NO. 3, (956-966), Online publication date: 1-Sep-2009.Canguven O, Lagoda G, Sezen S and Burnett A (2009) Losartan Preserves Erectile Function After Bilateral Cavernous Nerve Injury via Antifibrotic Mechanisms in Male RatsJournal of Urology, VOL. 181, NO. 6, (2816-2822), Online publication date: 1-Jun-2009. Volume 178Issue 2August 2007Page: 597-601 Advertisement Copyright & Permissions© 2007 by American Urological AssociationKeywordsprostatic neoplasmsimpotencepenisquality of lifeprostateMetricsAuthor Information Arthur L. Burnett Financial interest and/or other relationship with Pfizer, Lilly ICOS and Guilford/MGI Pharma. More articles by this author Gunnar Aus More articles by this author Edith D. Canby-Hagino More articles by this author Michael S. Cookson Financial interest and/or other relationship with Sanofi-Aventis, GlaxoSmithKline, Envisioneering Medical Technologies, Aeterna Zentaris Solvay, Photocure, National Institutes of Health and GTX. More articles by this author Anthony V. D'Amico More articles by this author Roger R. Dmochowski Financial interest and/or other relationship with Indevus, Watson Pharmaceuticals and Bard. More articles by this author David T. Eton More articles by this author Jeffrey D. Forman More articles by this author S. Larry Goldenberg More articles by this author Javier Hernandez More articles by this author Celestia S. Higano More articles by this author Stephen Kraus Financial interest and/or other relationship with National Institute for Diabetes and Digestive and Kidney Diseases, Pfizer, Astellas, Novartis and Ortho McNeil. More articles by this author Monica Liebert More articles by this author Judd W. Moul More articles by this author Catherine Tangen More articles by this author J. Brantley Thrasher More articles by this author Ian Thompson Financial interest and/or other relationship with Mission Pharmacal, AstraZeneca and National Institutes of Health. More articles by this author American Urological Association Prostate Cancer Guideline Update Panel More articles by this author Expand All Advertisement PDF downloadLoading ...