Lipoprotein and Lecithin: Cholesterol Acyltransferase Changes in Galactosamine-Induced Rat Liver Injury
1975; American Association for the Advancement of Science; Volume: 190; Issue: 4221 Linguagem: Inglês
10.1126/science.812181
ISSN1095-9203
AutoresSeymour M. Sabesin, L. B. Kuiken, James B. Ragland,
Tópico(s)Cancer, Lipids, and Metabolism
ResumoAbnormal lipoproteins and decreased lecithin: cholesterol acyltransferase activity are found in rat plasma following intraperitoneal injection of D-galactosamine. The changes observed, including absence of α-lipoprotein and the presence of lipoproteins rich in phospholipid and unesterified cholesterol but deficient in cholesteryl esters, are remarkably similar to changes found in human pathologic states of lecithin: cholesterol acyltransferase deficiency. When examined by electron microscopy, all of the major lipoprotein classes isolated by ultracentrifugation showed morphological abnormalities including the formation of rouleaus consisting of disk-shaped particles.
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