Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors
2013; Elsevier BV; Volume: 78; Issue: 3 Linguagem: Inglês
10.1016/j.steroids.2012.11.016
ISSN1878-5867
AutoresMichal Jurášek, Petr Džubák, David Sedlák, Hana Dvořáková, Marián Hajdúch, Petr Bartůněk, Pavel Drašar,
Tópico(s)Synthesis of β-Lactam Compounds
ResumoThere were synthesized new types of ribbon type steroidal dimers derived from three types of steroidal skeletons (cholic acid, etienic acid, estrone) using CuI catalyzed 1, 3-dipolar cycloaddition reaction. Steroid parts of the molecular "ribbons" are linked by heterocyclic moiety, namely by 2,6-bis((1H-1,2,3-triazol-1-yl)-methyl)pyridine. Compounds synthesized possess different cytotoxic and hormone receptor modulating activities.
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