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Cadinane sesquiterpenoids of Phomopsis cassiae, an endophytic fungus associated with Cassia spectabilis (Leguminosae)

2006; Elsevier BV; Volume: 67; Issue: 17 Linguagem: Inglês

10.1016/j.phytochem.2006.06.004

1873-3700

Geraldo Humberto Silva, Helder Lopes Teles, Lisinéia Maria Zanardi, Maria Cláudia Marx Young, Marcos N. Eberlin, Renato Moreira Hadad, Ludwig H. Pfenning, Claudio M. Costa‐Neto, Ian Castro‐Gamboa, Vanderlan da Silva Bolzani, Ângela R. Araújo,

Plant biochemistry and biosynthesis

Five cadinane sesquiterpenes derivatives were isolated by bioassay-guided fractionation from Phomopis cassiae, an endophytic fungus isolated from Cassia spectabilis. The structures of the two diastereoisomeric 3,9,12-trihydroxycalamenenes (1, 2); 3,12-dihydroxycalamenene (3); 3,12-dihydroxycadalene (4) and 3,11,12-trihydroxycadalene (5) were established on the basis of analyses of 1D and 2D NMR and HRTOFMS experiments. Antifungal activity of the isolates was evaluated against Cladosporium sphaerospermum and Cladosporium cladosporioides, revealing 5 as the most active compound.