Observations on the Dissolution Behavior of a Tablet Formulation: Effect of Compression Forces
1985; Elsevier BV; Volume: 74; Issue: 5 Linguagem: Inglês
10.1002/jps.2600740519
ISSN1520-6017
Autores Tópico(s)Analytical Methods in Pharmaceuticals
ResumoTwo test drugs, hydrochlorothiazide and phenylbutazone, were separately incorporated into a standard formulation to study their disintegration and dissolution properties as a function of compression force. The increase in dissolution with force was attributed to the manner in which tablets disintegrated while dissolving. At a fixed press setting, tablets from the same compression cycle showed variations in their dissolution which were in agreement with the observed effects of force on dissolution. A linear correlation between dissolution efficiency and the logarithm of force was found to exist over the compression range studied.
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