Penetration of Topically Applied Dexamethasone Alcohol Into Human Aqueous Humor
1988; American Medical Association; Volume: 106; Issue: 5 Linguagem: Inglês
10.1001/archopht.1988.01060130748037
ISSN1538-3601
AutoresDavid G. Watson, M Noble, Gordon N. Dutton, John M. Midgley, T. Healey,
Tópico(s)Ocular Infections and Treatments
ResumoGas chromatography combined with mass spectrometry was used to determine the absorption of topically applied dexamethasone alcohol into the aqueous humor of human subjects undergoing routine intraocular surgery. The dexamethasone concentration in aqueous humor was greatest in the interval between 91 and 120 minutes following instillation (mean concentration, 31 ng/mL). Dexamethasone was still detectable in the aqueous 12 hours after instillation.
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