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MHC class II molecules: transport pathways for antigen presentation

1997; Elsevier BV; Volume: 7; Issue: 3 Linguagem: Inglês

10.1016/s0962-8924(97)01000-3

1879-3088

Richard Wubbolts, Mai Fernandez-Bona, Jacques Neefjes,

T-cell and B-cell Immunology

During biosynthesis, MHC class II molecules travel through the endocytic pathway and interact with antigenic peptides before their stable insertion in the plasma membrane. The process of class II association with these peptides and their final deposition at the cell surface are essential steps in boosting specific antibody responses. Therefore, the study of class II molecules is important in understanding how cell-biological events can direct an immune response.