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Transfusion-Associated Babesiosis: Shouldn't We Be Ticked Off?

2011; American College of Physicians; Volume: 155; Issue: 8 Linguagem: Inglês

10.7326/0003-4819-155-8-201110180-00363

1539-3704

David A. Leiby,

Mosquito-borne diseases and control

Editorials18 October 2011Transfusion-Associated Babesiosis: Shouldn't We Be Ticked Off?FREEDavid A. Leiby, PhDDavid A. Leiby, PhDFrom American Red Cross Holland Laboratory, Rockville, MD 20855.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-8-201110180-00363 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Human babesiosis in the United States is attributable almost exclusively to infection with the intraerythrocytic protozoan parasite Babesia microti. The primary mechanism of parasite transmission to humans is by the bite of an infected deer/black-legged tick, Ixodes scapularis, the same tick that serves as the vector for Lyme borreliosis, human granulocytic anaplasmosis, and several other tick-borne diseases (1). Babesiosis is often described as an emerging infectious disease in the United States. The first documented case of clinical disease caused by B. microti was reported on Nantucket Island, Massachusetts, in 1969 (2). Since then, hundreds to thousands of babesiosis cases have been described, leading the Council of State and Territorial Epidemiologists to recommend that it be designated as a nationally notifiable disease beginning in January 2011 (3). Geographically, B. microti is limited primarily to endemic areas in the Northeast (Connecticut, Massachusetts, New Jersey, New York, and Rhode Island) and upper Midwest (Minnesota and Wisconsin); another species, B. duncani, is reported on rare occasions in California and Washington.Infections with B. microti produce a spectrum of disease, ranging from asymptomatic, self-resolving infections to severe, life-threatening illnesses that are often dictated by the host's immune status. Common signs and symptoms of babesiosis include fever, headache, chills, drenching sweats, myalgia, malaise, and hemolytic anemia. More severe cases frequently occur in immunocompromised populations, including neonates and infants, elderly persons, and asplenic patients. Complications of babesiosis may include acute respiratory distress, severe hemolysis, disseminated intravascular coagulation, renal dysfunction, hepatic compromise, myocardial infarction, and death.Concomitant with the emergence of babesiosis as a public health concern has been a proliferation of cases of transfusion-associated babesiosis. The first documented case of transfusion-transmitted Babesia was reported in Boston in 1979 (4). Subsequently, cases of babesiosis associated with blood transfusion have rapidly increased. For many years, based on largely anecdotal information, the number of transfusion-associated cases was estimated to be approximately 70. Determining an accurate tally of cases was deemed difficult because many transfusion cases were not reported in an organized manner or were not considered novel enough to justify publication. In this issue, Herwaldt and colleagues (5) have compiled an exhaustive list of known cases (n = 162) of transfusion-associated babesiosis from 1979 to 2009, which has important implications for public health and transfusion medicine. In the absence of a feasible and approved method for screening the blood supply, B. microti has become the infectious agent most frequently transmitted by blood transfusion in the United States.Herwaldt and colleagues state that their report probably undercounts transfusion-associated cases. They identified 159 cases of B. microti transmission during the 30-year study period (plus 3 additional cases attributed to B. duncani), but other, unreported cases have probably occurred. Systematic reporting of transfusion-associated babesiosis remains problematic. That physicians do not recognize babesial infections in blood recipients surely reduces the perceived number of cases. Even severe cases of babesiosis from endemic regions can be misdiagnosed. Among more than 20 index patients in whom intraerythrocytic ring forms were noted, at least 14 were initially treated for malaria. Further, incidental diagnosis of babesiosis also occurred, often unexpectedly, when parasites were detected on blood smears routinely done as part of a complete blood count. Case counts were also limited by the authors' selection criteria that required identification of an implicated donor based on laboratory evidence of infection (cases were excluded from consideration if all donors were negative). From my experience, follow-up studies of infected recipients frequently do not yield an infected donor (6). Infections in asymptomatic, immunocompetent donors are often short-lived and resolve spontaneously. By the time donors are evaluated for their potential role in transmission, they may be parasitologically and serologically negative. These observations suggest that many more cases of transfusion-associated babesiosis have occurred than the current publication suggests.Data presented by Herwaldt and colleagues also suggest that the number and frequency of transfusion-associated babesiosis cases are rapidly increasing. Whereas only 7 (4%) cases were reported during the initial 11 years (1979 to 1989) of study, 122 (77%) cases occurred from 2000 to 2009. This precipitous increase is corroborated by recently published reports from the U.S. Food and Drug Administration, Rhode Island Blood Center, American Red Cross, and the New York City Department of Mental Health and Hygiene (7–10). The observed increase in cases raises the question of whether the parasite's endemic range is expanding, if prospective donors are becoming infected more frequently, or if physicians and hospitals are more attuned to potential Babesia infections in blood recipients. As with many questions regarding emerging infectious agents, this is difficult to answer, but the explanation is probably multifactorial. Studies to define the geographic spread of the parasite are limited but should improve now that babesiosis is a notifiable disease. Although designated as a notifiable desease only since January, 314 cases of babesiosis have been reported to the Centers for Disease Control and Prevention through the week ending 20 August 2011 (11). Longitudinal seroprevalence studies done by the American Red Cross for more than 10 years in Connecticut blood donors indicate that the prevalence rate has remained near 1% throughout (12). However, where the endemic range of the parasite continues to expand, one can anticipate increased frequency of clinical and transfusion-associated cases. Despite the issues of case recognition discussed earlier, education efforts by the Centers for Disease Control and Prevention, AABB (formerly the American Association of Blood Banks), and state and local health departments during the past decade have led to a better understanding of the public health and transfusion risks posed by Babesia. As evidenced by transfusion-associated cases reported in states where Babesia is not endemic, physician awareness of babesiosis is becoming more widespread.Herwaldt and coworkers speculate that increasing recognition of transfusion cases will strengthen the impetus to mitigate transmission risk. Yet, several hurdles prevent implementation of an effective strategy. Presently, a blood screening assay (serologic or nucleic acid) licensed and approved by the U.S. Food and Drug Administration does not exist. In part, manufacturers have shown a reluctance to develop a test for a regionalized agent that may require only a limited number of tests compared with other agents (for example, HIV) that are screened universally. Although Babesia transmission risk clearly peaks during the summer months (that is, active tick season), it poses a significant risk year-round that will need to be addressed. Even though transfusion-associated cases of babesiosis attributable to traveling donors or blood products were reported in nonendemic states (for example, Florida and Texas), 87% of the cases compiled by Herwaldt and colleagues were reported in the 7 endemic states, suggesting that any intervention needs to target these regions first. The potential role of pathogen reduction, which has shown feasibility in research studies, also needs to be considered (13, 14). What is not acceptable, however, is the status quo. With reports of 162 transfusion-associated cases of babesiosis probably representing only a fraction of actual cases and a potential causal or contributory role for babesiosis in the deaths of B. microti–infected blood recipients, the time to act is now.David A. Leiby, PhDAmerican Red Cross Holland LaboratoryRockville, MD 20855References1. Leiby DA. Transfusion-transmitted Babesia spp.: bull's-eye on Babesia microti. . Clin Microbiol Rev. 2011;24:14-28. [PMID: 21233506] CrossrefMedlineGoogle Scholar2. Western KA, Benson GD, Gleason NN, Healy GR, Schultz MG. Babesiosis in a Massachusetts resident. N Engl J Med. 1970;283:854-6. [PMID: 4989787] CrossrefMedlineGoogle Scholar3. Council of State and Territorial Epidemiologists. CSTE List of Nationally Notifiable Conditions. June 2010. Accessed at www.cste.org/dnn/LinkClick.aspx?fileticket=KVo%2fcS9UR5Q%3d&tabid=36&mid=1496 on 30 August 2011. Google Scholar4. Jacoby GA, Hunt JV, Kosinski KS, Demirjian ZN, Huggins C, Etkind P, et al. Treatment of transfusion-transmitted babesiosis by exchange transfusion. N Engl J Med. 1980;303:1098-100. [PMID: 7191475] CrossrefMedlineGoogle Scholar5. Herwaldt BL, Linden JV, Bosserman E, Young C, Olkowska D, Wilson M. Transfusion-associated babesiosis in the United States: a description of cases. Ann Intern Med. 2011;155:509-19. [PMID: 7191475] LinkGoogle Scholar6. Johnson ST, Cable RG, Leiby DA. Lookback investigations of Babesia microti seropositive blood donors: seven year experience in a Babesia-endemic area. Transfusion. 2011;51. [Forthcoming]. Google Scholar7. Gubernot DM, Lucey CT, Lee KC, Conley GB, Holness LG, Wise RP. Babesia infection through blood transfusions: reports received by the US Food and Drug Administration, 1997-2007. Clin Infect Dis. 2009;48:25-30. [PMID: 19035776] CrossrefMedlineGoogle Scholar8. Asad S, Sweeney J, Mermel LA. Transfusion-transmitted babesiosis in Rhode Island. Transfusion. 2009;49:2564-73. [PMID: 19761547] CrossrefMedlineGoogle Scholar9. Tonnetti L, Eder AF, Dy B, Kennedy J, Pisciotto P, Benjamin RJ, et al. Transfusion-transmitted Babesia microti identified through hemovigilance. Transfusion. 2009;49:2557-63. [PMID: 19624607] CrossrefMedlineGoogle Scholar10. New York City Department of Health and Mental Hygiene. Health Advisory 5: increase in transfusion-associated babesiosis in NYC. 2008. Accessed at www.nyc.gov/html/doh/downloads/pdf/cd/2009/09md05.pdf on 30 August 2011. Google Scholar11. Centers for Disease Control and Prevention. Notifiable diseases and mortality tables. MMWR. 2011;60:1136-49. Google Scholar12. Johnson ST, Cable RG, Tonnetti L, Spencer B, Rios J, Leiby DA. Seroprevalence of Babesia microti in blood donors from Babesia-endemic areas of the northeastern United States: 2000 through 2007. Transfusion. 2009;49:2574-82. [PMID: 19821951] CrossrefMedlineGoogle Scholar13. Grellier P, Benach J, Labaied M, Charneau S, Gil H, Monsalve G, et al. Photochemical inactivation with amotosalen and long-wavelength ultraviolet light of Plasmodium and Babesia in platelet and plasma components. Transfusion. 2008;48:1676-84. [PMID: 18503613] CrossrefMedlineGoogle Scholar14. Tonnetti L, Proctor MC, Reddy HL, Goodrich RP, Leiby DA. Evaluation of the Mirasol pathogen [corrected] reduction technology system against Babesia microti in apheresis platelets and plasma. Transfusion. 2010;50:1019-27. [PMID: 20030791] CrossrefMedlineGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: From American Red Cross Holland Laboratory, Rockville, MD 20855.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M11-2032.Corresponding Author: David A. Leiby, PhD, Transmissible Diseases Department, American Red Cross Holland Laboratory, 15601 Crabbs Branch Way, Rockville, MD 20855; e-mail, [email protected]redcross.org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTransfusion-Associated Babesiosis in the United States: A Description of Cases Barbara L. Herwaldt , Jeanne V. Linden , Elizabeth Bosserman , Carolyn Young , Danuta Olkowska , and Marianna Wilson Metrics Cited ByHuman babesiosis: recent advances and future challengesZoonotic Babesia: A scoping review of the global evidenceBabesia divergens: A Drive to SurviveDetection and characterization of an emerging type of Babesia sp. similar to Babesia motasi for the first case of human babesiosis and ticks in KoreaCase report of the patient source of the Babesia microti R1 reference strain and implications for travelersHuman babesiosis: Indication of a molecular mimicry between thrombospondin domains from a novel Babesia microti BmP53 protein and host platelets moleculesCases of transfusion‐transmitted babesiosis occurring in nonendemic areas: a diagnostic dilemmaIs babesiosis the most common transfusion transmitted infection in the United States of America? The answer is not simple!Elimination of Babesia microti Is Dependent on Intraerythrocytic Killing and CD4 + T CellsA novel flow cytometric application discriminates among the effects of chemical inhibitors on various phases of Babesia divergens intraerythrocytic cycleTransmission of Babesia microti Parasites by Solid Organ TransplantationA targeted immunomic approach identifies diagnostic antigens in the human pathogen Babesia microtiHuman Babesiosis: Pathogens, Prevalence, Diagnosis, and TreatmentReceptor-ligand interactions underlying RBC invasion in BabesiaHuman Coinfection with Borrelia burgdorferi and Babesia microti in the United StatesA longitudinal study of Babesia microti infection in seropositive blood donorsScreening for babesiosis: where is the policy?Babesia : impact of cold storage on the survival and the viability of parasites in blood bagsCost-effectiveness of blood donor screening for Babesia microti in endemic regions of the United StatesBabesia: An Emerging Infectious Threat in Transfusion MedicineBeyond Lyme: Aetiology of Tick-borne Human Diseases with Emphasis on the South-Eastern United StatesHuman Babesiosis 18 October 2011Volume 155, Issue 8Page: 556-557KeywordsBabesiaBabesiosisBloodBlood banksBlood transfusionInfectious diseasesPrevention, policy, and public healthResearch laboratoriesTicksTransfusion medicine ePublished: 18 October 2011 Issue Published: 18 October 2011 CopyrightCopyright © 2011 by American College of Physicians. 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