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Scurvy and Altered Iron Stores in Thalassemia Major

1981; Massachusetts Medical Society; Volume: 304; Issue: 3 Linguagem: Inglês

10.1056/nejm198101153040307

1533-4406

Alan R. Cohen, Ian J. Cohen, Elias Schwartz,

Vitamin C and Antioxidants Research

SCURVY is a rare disorder in the United States because of the wide availability of fresh fruits and vegetables and the frequent supplementation of common packaged foods with vitamin C. Although vitamin C levels in leukocytes are reduced in many patients with iron overload due to repeated blood transfusions,1 clinical scurvy has not been reported in this group. We have studied a patient with homozygous β-thalassemia and iron overload, who had two episodes of scurvy despite a normal intake of vitamin C. Investigation of iron stores before treatment and during recovery showed that the normal release of iron from tissue . . .