Lactate dehydrogenase subunit and activity changes in hypertrophied heart of the hypoxically exposed rat
1974; Elsevier BV; Volume: 358; Issue: 1 Linguagem: Inglês
10.1016/0005-2744(74)90253-8
ISSN1878-1454
Autores Tópico(s)Spaceflight effects on biology
ResumoAbstract Rats were exposed to an atmospheric pressure as low as 342 mm Hg (6220 m) for 57 days. This resulted in marked increases in blood hemoglobin concentration and heart weight relative to sea level controls. The lactate dehydrogenase electrophoretic isozyme pattern was visibly altered in extracts from such hearts, showing increased staining density of cathodal components amounting to an 11.8% shift toward greater M-subunit composition. This resulted in such hearts from a more than 2-fold increase in M-subunit, while H-subunit increased only slightly. The sum of both subunit changes produced a 37.5% increase in total cardiac lactate dehydrogenase activity in hypoxically exposed animals as compared to controls.
Referência(s)