Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus
2004; Springer Nature; Volume: 61; Issue: 16 Linguagem: Inglês
10.1007/s00018-004-4222-9
ISSN1420-9071
AutoresJindřich Činátl, Gerold Hoever, Birgit Morgenstern, Wolfgang Preiser, Jens‐Uwe Vogel, W.-K. Hofmann, Gabriele Bauer, Martin Michaelis, Holger F. Rabenau, H. W. Doerr,
Tópico(s)Viral gastroenteritis research and epidemiology
ResumoTo identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a functional receptor. In both cell lines, SARS-CoV infection deregulated expression of cellular genes which may be important for the intestinal pathogenesis of SARS.
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