Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis

2012; Elsevier BV; Volume: 67; Issue: 3 Linguagem: Inglês

10.1016/j.biopha.2012.11.009

1950-6007

J.S. Ventura, Fernanda Faria, Isabel de Fátima Correia Batista, Simone Michaela Simons, Daniella Gorete Lourenço de Oliveira, Kátia L.P. Morais, Ana Marisa Chudzinski‐Tavassi,

Blood Coagulation and Thrombosis Mechanisms

Cancer is linked to hypercoagulability, and many studies have shown that anticoagulant drugs affect tumor progression. In this study was demonstrated that the Amblyomin-X (which is a recombinant protein that exerts similarity to the Kunitz-type inhibitors and shows pro-apoptotic effects in different tumor cell lines) and heparin (a classic anticoagulant) have similar effects on cancer progression and on normalization of the hypercoagulable state. However, Amblyomin-X showed a distinct mechanism in triggering its effects in vitro, because it exerted a cytotoxic effect in cancer cells by inducing apoptosis and promoting cell cycle arrest.