Portal de Periódicos da CAPES

Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD

2015; Society for Neuroscience; Volume: 35; Issue: 12 Linguagem: Inglês

10.1523/jneurosci.2842-14.2015

1529-2401

Philip Regan, Thomas M. Piers, Jee Hyun Yi, Dong‐Hyun Kim, Seonghoo Huh, Se Jin Park, Jong Hoon Ryu, Daniel J. Whitcomb, Kwangwook Cho,

Alzheimer's disease research and treatments

Tau is required for the induction of long-term depression (LTD) of synaptic transmission in the hippocampus. Here we probe the role of tau in LTD, finding that an AMPA receptor internalization mechanism is impaired in tau KO mice, and that LTD causes specific phosphorylation at the serine 396 and 404 residues of tau. Surprisingly, we find that phosphorylation at serine 396, specifically, is critical for LTD but has no role in LTP. Finally, we show that tau KO mice exhibit deficits in spatial reversal learning. These findings underscore the physiological role for tau at the synapse and identify a behavioral correlate of its role in LTD.