Solid‐phase total synthesis of polymyxin B1
1999; Wiley; Volume: 53; Issue: 5 Linguagem: Inglês
10.1034/j.1399-3011.1999.00045.x
ISSN1399-3011
AutoresSushil K. Sharma, Arthur Wu, Nagarajan Chandramouli, Christopher Fotsch, G. Kardash, Kenneth W. Bair,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoThe total solid-phase synthesis of polymyxin B1 (PMB1) has been achieved in 20% yield using the orthogonal protecting group N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-(Dde). This report demonstrates that a complex peptide macrocycle can be synthesized in high yields using solid-phase synthesis. According to MS and HPLC, the synthetic peptide was identical to the naturally occurring antibiotic.
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