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Iatrogenic Cushing syndrome after intra-articular triamcinolone in a patient receiving ritonavir-boosted darunavir

2013; SAGE Publishing; Volume: 24; Issue: 9 Linguagem: Inglês

10.1177/0956462413480723

1758-1052

Jill Hall, Christine Hughes, Michelle Foisy, Stan Houston, Stephen Shafran,

Adrenal Hormones and Disorders

Drug interactions involving human immunodeficiency virus protease inhibitors are common due to their inhibition of the cytochrome P450 3A4 isoenzyme. We describe the case of an HIV-infected patient treated with ritonavir-boosted darunavir who developed cushingoid features following an intra-articular injection of triamcinolone acetate. We review the probable mechanism for this interaction and describe similar cases of Cushing syndrome in patients receiving concomitant ritonavir and triamcinolone.