Fully automated synthesis of 13N-labeled nitrosothiols
2010; Elsevier BV; Volume: 51; Issue: 22 Linguagem: Inglês
10.1016/j.tetlet.2010.03.122
ISSN1873-3581
AutoresVanessa Gómez‐Vallejo, Koichi Kato, Iosu Oliden, Javier Calvo, Zuriñe Baz, José I. Borrell, Jordi Llop,
Tópico(s)Electron Spin Resonance Studies
ResumoIn the present Letter, a fast, automated, and reproducible method for the synthesis of S-[13N]nitrosothiols is reported. The labeling strategy is based on trapping [13N]NO2- in an anion exchange resin. The reaction with thiols in acidic media led to the formation of the desired nitrosothiols in short reaction times (60 s) with excellent radiochemical conversions (from 48.7% to 74.5%). Final radiotracers were purified by HPLC. Good radiochemical yields (from 33.8% to 60.6%, decay corrected) and radiochemical purities (>99%) were obtained in all cases. Stability of the labeled compounds was checked.
Referência(s)