Physical Stability of Amorphous Acetanilide Derivatives Improved by Polymer Excipients
2006; Pharmaceutical Society of Japan; Volume: 54; Issue: 8 Linguagem: Inglês
10.1248/cpb.54.1207
ISSN1347-5223
AutoresTamaki Miyazaki, Sumie Yoshioka, Yukio Aso,
Tópico(s)Thermal and Kinetic Analysis
ResumoCrystallization rates of drug-polymer solid dispersions prepared with acetaminophen (ACA) and p-aminoacetanilide (AAA) as model drugs, and polyvinylpyrrolidone and polyacrylic acid (PAA) as model polymers were measured in order to further examine the significance of drug–polymer interactions. The crystallization of AAA and ACA was inhibited by mixing those polymers. The most effective inhibition was observed with solid dispersions of AAA and PAA. The combination of AAA and PAA showed a markedly longer enthalpy relaxation time relative to drug alone as well as a higher Tg than predicted by the Gordon–Taylor equation, indicating the existence of a strong interaction between the two components. These observations suggest that crystallization is effectively inhibited by combinations of drug and polymer that show a strong intermolecular interaction due to proton transfer between acidic and basic functional groups.
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