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Catalytic Asymmetric Reductive Amination of α-Branched Ketones

2010; Wiley; Volume: 49; Issue: 27 Linguagem: Inglês

10.1002/anie.201001715

1521-3773

Vijay N. Wakchaure, Jian Zhou, S.D. Hoffmann, Benjamin List,

Advanced Synthetic Organic Chemistry

Branching out: An organocatalytic reductive amination of α-branched ketones using dynamic kinetic resolution is reported. The cis-2-substituted cyclohexyl amines were obtained in high diastereoselectivity and enantioselectivity from the corresponding ketones. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.