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Heparin-associated thrombocytopenia and thrombosis as the cause of a fatal thrombus on extracorporeal membrane oxygenation

1997; Elsevier BV; Volume: 32; Issue: 5 Linguagem: Inglês

10.1016/s0022-3468(97)90031-2

1531-5037

Thomas Bütler, Laura J. Sodoma, John J. Doski, Henry W. Cheu, Sven T. Berg, Gary N. Stokes, Kristen Lancaster,

Venous Thromboembolism Diagnosis and Management

A rare state of acquired hypercoagulability known as heparin-associated or heparin-induced thrombocytopenia and thrombosis (HATT, HITT) exists. It appears to be caused by an antibody reaction with heparin-platelet factor 4 complexes. A mild and severe form exist, but both varieties occur after exposure to heparin. The authors describe a fatal neonatal case of hypercoagulability on extracorporeal membrane oxygenation, and their evaluation that determined the etiology as type II HATT. They discuss the pathophysiology of HATT as well as possible alternative anticoagulation approaches.