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Efficacy of ( S )‐1‐(3‐hydroxy‐2‐phosphonylmethoxypropyl)cytosine and 9‐(1,3‐dihydroxy‐2‐propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice

1992; Wiley; Volume: 37; Issue: 1 Linguagem: Inglês

10.1002/jmv.1890370112

1096-9071

Johan Neyts, Jan Balzarini, Lieve Naesens, Erik De Clercq,

Immune Cell Function and Interaction

Abstract Mice with severe combined immunodeficiency (SCID) inoculated intraperitoneally with murine cytornegalovirus (MCMV) develop a wasting syndrome at 3–4 days and die at 6–9 days after the infection. 9‐(1,3‐Dihydroxy‐2‐propoxyrnethyl)guanine (DHPG, ganciclovir) and ( S )‐1‐(3‐hydroxy‐2‐phosphonylrnethoxypropyl) cytosine (HPMPC) were compared for their efficacy against MCMV‐induced disease and mortality in SCID mice. Under all treatment conditions, i.e., administration of the test compounds for 5 consecutive days starting on the day of infection (day 0), for 5 consecutive days starting on day 4 after the infection, 2 periods of 3 consecutive days starting on day 0 and day 9 after infection, or as a single dose on day 3 before infection, HPMPC proved far superior to ganciclovir in delaying the onset of the disease and increasing the lifespan of the MCMV‐infected mice. © 1992 Wiley‐Liss, Inc.