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Oxygen Affinity of Hemoglobin in Persons with Acute Myocardial Infarction and in Smokers

1966; Lippincott Williams & Wilkins; Volume: 34; Issue: 2 Linguagem: Inglês

10.1161/01.cir.34.2.331

1524-4539

Robert S. Eliot, Hiroshi Mizukami,

Heme Oxygenase-1 and Carbon Monoxide

HomeCirculationVol. 34, No. 2Oxygen Affinity of Hemoglobin in Persons with Acute Myocardial Infarction and in Smokers Free AccessResearch ArticlePDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessResearch ArticlePDF/EPUBOxygen Affinity of Hemoglobin in Persons with Acute Myocardial Infarction and in Smokers ROBERT S. ELIOT, M.D. and HIROSHI MIZUKAMI, PH.D. ROBERT S. ELIOTROBERT S. ELIOT From the Department of Medicine, University of Minnesota Medical School, and the Department of Chemistry, University of Minnesota, Minneapolis, Minnesota. Search for more papers by this author and HIROSHI MIZUKAMIHIROSHI MIZUKAMI From the Department of Medicine, University of Minnesota Medical School, and the Department of Chemistry, University of Minnesota, Minneapolis, Minnesota. Search for more papers by this author Originally published1 Aug 1966https://doi.org/10.1161/01.CIR.34.2.331Circulation. 1966;34:331–336AbstractThe hemoglobin-oxygen affinity of pure hemoglobin was studied in 11 patients with signs of myocardial ischemia or acute necrosis and in 12 controls. Additionally, the hemoglobin of a moderate and a heavy cigarette smoker without evidence of cardiovascular disease was studied. Under physiological pH conditions, the hemoglobin gave up oxygen in an abnormal manner in all except the 12 controls.In all control subjects and patients, the arterial saturation was normal and blood pH values were within normal limits. Electrophoretic abnormality was not found in any of the subjects studied. It is thus demonstrated that hemoglobin may be physicochemically abnormal without electrophoretic abnormality. From a functional point of view, the hemoglobin's abnormal response to changes in oxygenation may result from altered proton-binding properties of the hemoglobin molecule. That such "abnormal" hemoglobin could contribute to the paradox of myocardial ischemia or necrosis occurring in the presence of full arterial saturation and patent coronary arteries is not certain from these studies.Further studies investigating the role of abnormal hemoglobin-oxygen affinity in the pathophysiology of myocardial ischemia or necrosis appear justified and necessary. Previous Back to top Next FiguresReferencesRelatedDetailsCited By Mirza A (2003) Myocardial infarction resulting from nonatherosclerotic coronary artery diseases, The American Journal of Emergency Medicine, 10.1016/S0735-6757(03)00104-9, 21:7, (578-584), Online publication date: 1-Nov-2003. 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Likoff W, Segal B and Kasparian H (1967) Paradox of Normal Selective Coronary Arteriograms in Patients Considered to Have Unmistakable Coronary Heart Disease, New England Journal of Medicine, 10.1056/NEJM196705112761904, 276:19, (1063-1066), Online publication date: 11-May-1967. August 1, 1966Vol 34, Issue 2 Advertisement Article InformationMetrics © 1966 American Heart Association, Inc.https://doi.org/10.1161/01.CIR.34.2.331 Originally publishedAugust 1, 1966 PDF download Advertisement