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Effect of growth hormone, insulin, thyroxine and cortisone on renal gluconeogenesis

1968; Elsevier BV; Volume: 127; Linguagem: Inglês

10.1016/0003-9861(68)90228-2

1096-0384

P. K. Joseph, K Subrahmanyam,

Glycogen Storage Diseases and Myoclonus

Gluconeogenesis in kidney cortical slices of rats under different conditions was studied in the presence of glutamate, pyruvate and succinate as substrates. Slices obtained from rats treated with growth hormone exhibited a marked increase in gluconeogenesis with pyruvate and succinate as substrates, but not with glutamate. Slices obtained from alloxan-diabetic rats gave rise to similar increase in gluconeogenesis in the presence of all the three substrates compared with slices from normal rats. Prior administration of insulin depressed the gluconeogenesis in slices of diabetic rats to normal levels with all the three substrates. Administration of dl-Thyroxine gave rise to a significant increase in gluconeogenesis only with pyruvate as substrate. Kidney cortical slices obtained from cortisone treated rats were found to exhibit increased gluconeogenesis with succinate, pyruvate and glutamate.