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Sodium Glucose Co-Transporter-2 (SGLT2) Inhibitors: A Review of Their Basic and Clinical Pharmacology

2014; Adis, Springer Healthcare; Volume: 5; Issue: 2 Linguagem: Inglês

10.1007/s13300-014-0089-4

1869-6961

Sanjay Kalra,

Drug Transport and Resistance Mechanisms

Sodium-glucose co-transporter-2 (SGLT2) inhibitors are a newly developed class of oral anti-diabetic drugs (OADs) with a unique mechanism of action. This review describes the biochemistry and physiology underlying the use of SGLT2 inhibitors, and their clinical pharmacology, including mechanism of action and posology. The pragmatic placement of these molecules in the existing OAD arena is also discussed.