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Approach to High-Resolution ex Situ NMR Spectroscopy

2001; American Association for the Advancement of Science; Volume: 293; Issue: 5527 Linguagem: Inglês

10.1126/science.1061498

1095-9203

Carlos A. Meriles, Dimitris Sakellariou, Henrike Heise, Adam J. Moulé, Alexander Pines,

Advanced MRI Techniques and Applications

Nuclear magnetic resonance (NMR) experiments are typically performed with samples immersed in a magnet shimmed to high homogeneity. However, there are many circumstances in which it is impractical or undesirable to insert objects or subjects into the bore of a high-field magnet. Here we present a methodology based on an adaptation of nutation echoes that provides resolved spectra in the presence of matched inhomogeneous static and radiofrequency fields, thereby opening the way to high-resolution ex situ NMR. The observation of chemical shifts is regained through the use of multiple-pulse sequences of correlated, composite z-rotation pulses, producing resolved NMR spectra of liquid samples.