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Role of reproductive factors on the risk of endometrial cancer

1998; Wiley; Volume: 76; Issue: 6 Linguagem: Inglês

10.1002/(sici)1097-0215(19980610)76

1097-0215

Fabio Parazzini, Eva Negri, Carlo La Vecchia, G Benzi, Francesça Chiaffarino, Anna Polatti, Silvia Franceschi,

Ovarian cancer diagnosis and treatment

International Journal of CancerVolume 76, Issue 6 p. 784-786 Human CancerFree Access Role of reproductive factors on the risk of endometrial cancer Fabio Parazzini, Corresponding Author Fabio Parazzini Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy I Clinica Ostetrico Ginecologica, Università di Milano, Milan, Italy Centro di Riferimento Oncologico, Aviano (PN), ItalyIstituto di Ricerche Farmacologiche "Mario Negri", via Eritrea, 62, I-20157 Milan, Italy. Fax: (39)2-33200231Search for more papers by this authorEva Negri, Eva Negri Istituto di Ricerche Farmacologiche "Mario Negri," Milan, ItalySearch for more papers by this authorCarlo La Vecchia, Carlo La Vecchia Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy Istituto di Statistica Medica e Biometria, Università di Milano, Milan, ItalySearch for more papers by this authorGuido Benzi, Guido Benzi I Clinica Ostetrico Ginecologica, Università di Milano, Milan, ItalySearch for more papers by this authorFrancesca Chiaffarino, Francesca Chiaffarino Istituto di Ricerche Farmacologiche "Mario Negri," Milan, ItalySearch for more papers by this authorAnna Polatti, Anna Polatti I Clinica Ostetrico Ginecologica, Università di Milano, Milan, ItalySearch for more papers by this authorSilvia Franceschi, Silvia Franceschi Centro di Riferimento Oncologico, Aviano (PN), ItalySearch for more papers by this author Fabio Parazzini, Corresponding Author Fabio Parazzini Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy I Clinica Ostetrico Ginecologica, Università di Milano, Milan, Italy Centro di Riferimento Oncologico, Aviano (PN), ItalyIstituto di Ricerche Farmacologiche "Mario Negri", via Eritrea, 62, I-20157 Milan, Italy. Fax: (39)2-33200231Search for more papers by this authorEva Negri, Eva Negri Istituto di Ricerche Farmacologiche "Mario Negri," Milan, ItalySearch for more papers by this authorCarlo La Vecchia, Carlo La Vecchia Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy Istituto di Statistica Medica e Biometria, Università di Milano, Milan, ItalySearch for more papers by this authorGuido Benzi, Guido Benzi I Clinica Ostetrico Ginecologica, Università di Milano, Milan, ItalySearch for more papers by this authorFrancesca Chiaffarino, Francesca Chiaffarino Istituto di Ricerche Farmacologiche "Mario Negri," Milan, ItalySearch for more papers by this authorAnna Polatti, Anna Polatti I Clinica Ostetrico Ginecologica, Università di Milano, Milan, ItalySearch for more papers by this authorSilvia Franceschi, Silvia Franceschi Centro di Riferimento Oncologico, Aviano (PN), ItalySearch for more papers by this author First published: 06 December 1998 https://doi.org/10.1002/(SICI)1097-0215(19980610)76:6 3.0.CO;2-UCitations: 53AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract We analyzed the role of reproductive factors on the risk of endometrial cancer using data from a case-control study conducted in Italy. Cases were 752 women with histologically confirmed endometrial cancer <75 years of age. Controls were 2,606 patients <75 years of age admitted for acute, non-gynecological non-hormone-related, non-neoplastic conditions to the same network of hospitals where cases had been identified. In comparison with nulliparae, the risk of endometrial cancer tended to be lower in parous women, and the estimated multivariate odds ratios (ORs) were 0.9, 0.8 and 0.7, respectively, for women reporting 1, 2 and 3 or more births (χ12 trend 10.21). In comparison with women reporting no induced abortion, the ORs of endometrial cancer were 0.6 in women reporting 1 and 0.4 in those reporting 2 or more induced abortions. When considering parous women only, in comparison with women reporting their last birth 20 years before or longer, the ORs of endometrial cancer were 0.6 in those reporting their last birth 10–19 years before and 0.3 in those reporting their last birth <10 years before. Our results confirm and further quantify a protective role of pregnancy on the risk of endometrial cancer and provide insights on the time-risk relationship between pregnancy and cancer of corpus uteri. Int. J. Cancer 76:784–786, 1998.© 1998 Wiley-Liss, Inc. Citing Literature Volume76, Issue610 June 1998Pages 784-786 ReferencesRelatedInformation