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BIBTEX RIS

Polymorphism: an evaluation of the potential risk to the quality of drug products from the Farmácia Popular Rede Própria

2014; UNIVERSIDADE DE SÃO PAULO; Volume: 50; Issue: 1 Linguagem: Inglês

10.1590/s1984-82502011000100002

ISSN

2175-9790

Autores

Olímpia Maria Martins Santos, Maria Esther Dias Reis, Jennifer Tavares Jacon Freitas, Mônica Esselin de Sousa Lino, Juliana Savioli Simões, A.C. Doriguetto,

Tópico(s)

Pharmaceutical Quality and Counterfeiting

Resumo

Polymorphism in solids is a common phenomenon in drugs, which can lead to compromised quality due to changes in their physicochemical properties, particularly solubility, and, therefore, reduce bioavailability. Herein, a bibliographic survey was performed based on key issues and studies related to polymorphism in active pharmaceutical ingredient (APIs) present in medications from the Farmácia Popular Rede Própria. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns.

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