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Light‐Activated Release of Nitric Oxide with Fluorescence Reporting in Living Cells

2011; Wiley; Volume: 6; Issue: 9 Linguagem: Inglês

10.1002/cmdc.201100198

1860-7187

Elisa Vittorino, Maria Teresa Sciortino, Gabriel Siracusano, Salvatore Sortino,

Nanoplatforms for cancer theranostics

Prison break! A nitric oxide (NO) photocage incorporating a masked fluorescent unit within the same molecular skeleton allows the photoregulated release of NO within a cell, leading to cytotoxicity. Concomitant release of a strongly fluorescent co-product serves as an optical reporter for intracellular NO release.