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Heterodinuclear Zinc(II)−Iron(III) Complexes and Dinuclear Zinc Complexes as Models for Zinc-Containing Phosphatases

2002; Wiley; Volume: 2002; Issue: 6 Linguagem: Inglês

10.1002/1099-0682(200206)2002

1099-0682

S. Albedyhl, David Schnieders, Attila Jancsó, Tamás Gajda, Bernt Krebs,

ATP Synthase and ATPases Research

European Journal of Inorganic ChemistryVolume 2002, Issue 6 p. 1400-1409 Full Paper Heterodinuclear Zinc(II)−Iron(III) Complexes and Dinuclear Zinc Complexes as Models for Zinc-Containing Phosphatases Sabine Albedyhl, Sabine Albedyhl Anorganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Straße 8, 48149 Münster, Germany, Fax: (internat.) + 49-(0)251/83-38366Search for more papers by this authorDavid Schnieders, David Schnieders Anorganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Straße 8, 48149 Münster, Germany, Fax: (internat.) + 49-(0)251/83-38366Search for more papers by this authorAttila Jancsó, Attila Jancsó Department of Inorganic and Analytical Chemistry, University of Szeged, P. O. Box 440, 6701 Szeged, Hungary, Fax: (internat.) + 36-(0)62/420-505Search for more papers by this authorTamás Gajda, Tamás Gajda tamas.gajda@chem.u-szeged.hu Department of Inorganic and Analytical Chemistry, University of Szeged, P. O. Box 440, 6701 Szeged, Hungary, Fax: (internat.) + 36-(0)62/420-505Search for more papers by this authorBernt Krebs, Bernt Krebs krebs@uni-muenster.de Anorganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Straße 8, 48149 Münster, Germany, Fax: (internat.) + 49-(0)251/83-38366Search for more papers by this author Sabine Albedyhl, Sabine Albedyhl Anorganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Straße 8, 48149 Münster, Germany, Fax: (internat.) + 49-(0)251/83-38366Search for more papers by this authorDavid Schnieders, David Schnieders Anorganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Straße 8, 48149 Münster, Germany, Fax: (internat.) + 49-(0)251/83-38366Search for more papers by this authorAttila Jancsó, Attila Jancsó Department of Inorganic and Analytical Chemistry, University of Szeged, P. O. Box 440, 6701 Szeged, Hungary, Fax: (internat.) + 36-(0)62/420-505Search for more papers by this authorTamás Gajda, Tamás Gajda tamas.gajda@chem.u-szeged.hu Department of Inorganic and Analytical Chemistry, University of Szeged, P. O. Box 440, 6701 Szeged, Hungary, Fax: (internat.) + 36-(0)62/420-505Search for more papers by this authorBernt Krebs, Bernt Krebs krebs@uni-muenster.de Anorganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Straße 8, 48149 Münster, Germany, Fax: (internat.) + 49-(0)251/83-38366Search for more papers by this author First published: 27 April 2002 https://doi.org/10.1002/1099-0682(200206)2002:6 3.0.CO;2-QCitations: 50Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Five new dinuclear model complexes for zinc-containing phosphatases with dinucleating ligands have been prepared and characterized by single-crystal X-ray crystallography. The heterodinuclear, μ-alkoxo-bridged zinc(II)−iron(III) complexes 1−3 contain the symmetric ligands N,N,N′,N′-tetrakis[2-(5,6-dimethyl)benzimidazolylmethyl]-1,3-diamino-2propanol (Htdmbpo) and N,N,N′,N′-tetrakis{2-[N′′-(2hydroxyethyl)]benzimidazolylmethyl}-1,3-diamino-2-propanol (Hthebpo), and the asymmetric ligand N,N-bis[2-(4,5-dimethyl)benzimidazolylmethyl]-N′,N′-bis(2-pyridylmethyl)-1,3-diamino-2-propanol (Hbdmbbppo), respectively. X-ray crystallography revealed that the zinc center exhibits a trigonal-bipyramidal coordination, while the octahedral coordination sphere of the iron center is completed by a solvent molecule. In contrast, the zinc complexes 4 and 5, which also have (alkoxo)(cacodylato)dimetal cores with the dinucleating ligands used in 1 and 3, exhibit both metal centers in a trigonal-bipyramidal environment. Additionally, the solution speciation of the zinc(II) complexes formed with Htdmbpo and Hbdmbbppo were determined and the activity of the in situ prepared zinc complexes towards the transesterification of the RNA model substrate 2-(hydroxypropyl)-4-nitrophenyl phosphate (hpnp) was investigated. The dinuclear [Zn2LH−1(OH)]2+ complex of both ligands efficiently promotes the transesterification. The kinetic data indicated a higher activity for the complex of the asymmetric ligand Hbdmbbppo, as a result of its stronger substrate binding ability. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002) Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2005/2002/i01334_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume2002, Issue6June 2002Pages 1400-1409 RelatedInformation