2164 DE NOVO KIDNEY GRAFT TUMORS: RESULTS FROM A MULTICENTRIC RETROSPECTIVE NATIONAL STUDY
2010; Lippincott Williams & Wilkins; Volume: 183; Issue: 4S Linguagem: Inglês
10.1016/j.juro.2010.02.2267
ISSN1527-3792
AutoresX. Tillou, Jean Jacques Patard, Lionel Badet, Benoı̂t Barrou, Maxime Audet, H. Bensadoun, E. Berthoux, Pierre Bigot, Jean Michel Boutin, Ivan Bouzguenda, Damien Chambade, R. Codas, Jacques Dantal, J. Deturmeny, M. Devonec, A. Doerfler, B. Doré, F. Dugardin, Jean Ferrière, A. Erauso, B. Feuillu, B Gattegno, Marc Gigante, Laurent Guy, Georges Karam, Francois Kleinclaus, Thierry Lebrét, É. Lechevallier, Christophe Legendre, Christiane Mousson, Y. Neuzillet, Jean Philippe Rerolle, Thomas H. Perez, Laurent Salomon, Federico Sallusto, C. Sénéchal, Jacques Petit, N. Terrier, Rodolphe Thuret, G. Verhoest,
Tópico(s)Renal Transplantation Outcomes and Treatments
ResumoYou have accessJournal of UrologyTransplantation & Vascular Surgery: Renal Transplantation, Vascular Surgery II1 Apr 20102164 DE NOVO KIDNEY GRAFT TUMORS: RESULTS FROM A MULTICENTRIC RETROSPECTIVE NATIONAL STUDY Xavier Tillou, Jean Jacques Patard, Lionel Badet, Benoit Barrou, Maxime Audet, Henri Bensadoun, Emilie Berthoux, Pierre Bigot, Jean Michel Boutin, Ivan Bouzguenda, Damien Chambade, Ricardo Codas, Jacques Dantal, Julien Deturmeny, Marian Devonec, Arnaud Doerfler, Bertrand Dore, Fabrice Dugardin, Jean Marie Ferrière, Antoine Erauso, Benoit Feuillu, Bernard Gattegno, Marc Gigante, Laurent Guy, Georges Karam, Francois Kleinclaus, Thierry Lebret, Eric Lechevallier, Christophe Legendre, Christiane Mousson, Yann Neuzillet, Jean Philippe Rerolle, Thomas Perez, Laurent Salomon, Federico Sallusto, Cédric Sénéchal, Jacques Petit, Nicolas Terrier, Rodolphe Thuret, and Gregory Verhoest Xavier TillouXavier Tillou Amiens, France More articles by this author , Jean Jacques PatardJean Jacques Patard Rennes, France More articles by this author , Lionel BadetLionel Badet Lyon, France More articles by this author , Benoit BarrouBenoit Barrou Paris, France More articles by this author , Maxime AudetMaxime Audet Strasbourg, France More articles by this author , Henri BensadounHenri Bensadoun Caen, France More articles by this author , Emilie BerthouxEmilie Berthoux Saint Etienne, France More articles by this author , Pierre BigotPierre Bigot Angers, France More articles by this author , Jean Michel BoutinJean Michel Boutin Tours, France More articles by this author , Ivan BouzguendaIvan Bouzguenda Lille, France More articles by this author , Damien ChambadeDamien Chambade Paris, France More articles by this author , Ricardo CodasRicardo Codas Lyon, France More articles by this author , Jacques DantalJacques Dantal Nantes, France More articles by this author , Julien DeturmenyJulien Deturmeny Marseille, France More articles by this author , Marian DevonecMarian Devonec Lyon, France More articles by this author , Arnaud DoerflerArnaud Doerfler Paris, France More articles by this author , Bertrand DoreBertrand Dore Poitiers, France More articles by this author , Fabrice DugardinFabrice Dugardin Rouen, France More articles by this author , Jean Marie FerrièreJean Marie Ferrière Bordeaux, France More articles by this author , Antoine ErausoAntoine Erauso Brest, France More articles by this author , Benoit FeuilluBenoit Feuillu Nancy, France More articles by this author , Bernard GattegnoBernard Gattegno Paris, France More articles by this author , Marc GiganteMarc Gigante Nice, France More articles by this author , Laurent GuyLaurent Guy Clermont Ferrand, France More articles by this author , Georges KaramGeorges Karam Nantes, France More articles by this author , Francois KleinclausFrancois Kleinclaus Besançon, France More articles by this author , Thierry LebretThierry Lebret Suresnes, France More articles by this author , Eric LechevallierEric Lechevallier Marseille, France More articles by this author , Christophe LegendreChristophe Legendre Paris, France More articles by this author , Christiane MoussonChristiane Mousson Dijon, France More articles by this author , Yann NeuzilletYann Neuzillet Suresnes, France More articles by this author , Jean Philippe RerolleJean Philippe Rerolle Limoges, France More articles by this author , Thomas PerezThomas Perez Reims, France More articles by this author , Laurent SalomonLaurent Salomon Créteil, France More articles by this author , Federico SallustoFederico Sallusto Toulouse, France More articles by this author , Cédric SénéchalCédric Sénéchal Point à Pitre, France More articles by this author , Jacques PetitJacques Petit Amiens, France More articles by this author , Nicolas TerrierNicolas Terrier Grenoble, France More articles by this author , Rodolphe ThuretRodolphe Thuret Montpellier, France More articles by this author , and Gregory VerhoestGregory Verhoest Rennes, France More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.2267AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES De novo tumors in renal allografts are rare and their incidence is probably underestimated. Knowing the prognosis of such tumors is important for better tailoring immunosuppressive therapies, deciding upon safe oncological treatments and preventing return to dialysis. We therefore analyzed epidemiology, diagnosis, treatment and outcomes features of renal cell carcinomas (RCCs) arising in renal allografts through a large retrospective renal transplant cohort in France. METHODS We performed a retrospective and multicentric survey by sending questionnaires to all French kidney transplantation centers. All kidney graft tumors diagnosed after transplantation were considered as de novo tumors. The following variables were recorded in all cases: age, sex, delay between renal transplantation and occurrence of RCC, mode of diagnosis, TNM stage, Fuhrman grade, tumor size, histological subtype, renal function and oncological outcomes. RESULTS Thirty two centers participated in this study. Seventy one de novo kidney graft tumors were identified among 40407 patients who underwent a renal transplantation during the same period (0.17%). Patients were 48 men (67.6%) and 23 (32.4%) women with a mean age of 49 years (20-82) at the time of diagnosis. Mean tumor size was 3.2 cm (1.2-10). Tumor related symptoms were noted in only 11 patients (15.5%). Sixty one (85.9%), 44 (62.7 %) and 30 tumors (42.2%) were organ confined (T1-2), low grade (G1-2), and papillary carcinomas, respectively. Only 3 patients had synchronous distant metastases (4.2%). Mean time between transplantation and RCC diagnosis was 122.6 months (0.9-300). Thirty five (49.3%) and 5 (7%) patients underwent a conservative treatment by partial nephrectomy and radiofrequency ablation, respectively. Estimated 5 years cancer specific survival rate was 96%. CONCLUSIONS This is the largest series of RCCs arising in renal allografts reported so far. Even though occurring in the context of immune suppression, most of these tumors are small, incidental, low stage and low grade carcinomas. Papillary histology is more frequent than in the general RCC population suggesting that distinct molecular pathways are involved in that setting. Oncological outcome is excellent and conservative treatment should be preferred at each time it is feasible for preventing return to dialysis. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e842 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Xavier Tillou Amiens, France More articles by this author Jean Jacques Patard Rennes, France More articles by this author Lionel Badet Lyon, France More articles by this author Benoit Barrou Paris, France More articles by this author Maxime Audet Strasbourg, France More articles by this author Henri Bensadoun Caen, France More articles by this author Emilie Berthoux Saint Etienne, France More articles by this author Pierre Bigot Angers, France More articles by this author Jean Michel Boutin Tours, France More articles by this author Ivan Bouzguenda Lille, France More articles by this author Damien Chambade Paris, France More articles by this author Ricardo Codas Lyon, France More articles by this author Jacques Dantal Nantes, France More articles by this author Julien Deturmeny Marseille, France More articles by this author Marian Devonec Lyon, France More articles by this author Arnaud Doerfler Paris, France More articles by this author Bertrand Dore Poitiers, France More articles by this author Fabrice Dugardin Rouen, France More articles by this author Jean Marie Ferrière Bordeaux, France More articles by this author Antoine Erauso Brest, France More articles by this author Benoit Feuillu Nancy, France More articles by this author Bernard Gattegno Paris, France More articles by this author Marc Gigante Nice, France More articles by this author Laurent Guy Clermont Ferrand, France More articles by this author Georges Karam Nantes, France More articles by this author Francois Kleinclaus Besançon, France More articles by this author Thierry Lebret Suresnes, France More articles by this author Eric Lechevallier Marseille, France More articles by this author Christophe Legendre Paris, France More articles by this author Christiane Mousson Dijon, France More articles by this author Yann Neuzillet Suresnes, France More articles by this author Jean Philippe Rerolle Limoges, France More articles by this author Thomas Perez Reims, France More articles by this author Laurent Salomon Créteil, France More articles by this author Federico Sallusto Toulouse, France More articles by this author Cédric Sénéchal Point à Pitre, France More articles by this author Jacques Petit Amiens, France More articles by this author Nicolas Terrier Grenoble, France More articles by this author Rodolphe Thuret Montpellier, France More articles by this author Gregory Verhoest Rennes, France More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
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