PROTECTION OF THE TRYPTOPHAN INDOLE RING IN PEPTIDE SYNTHESIS. USE OF A NEW DERIVATIVE, N in -2,2,2-TRICHLOROETHOXYCARBONYLTRYPTOPHAN
1983; Oxford University Press; Volume: 12; Issue: 5 Linguagem: Inglês
10.1246/cl.1983.739
ISSN1348-0715
AutoresYoshiaki Kiso, Masatoshi Inai, Kouki Kitagawa, Tadashi Akita,
Tópico(s)Radiopharmaceutical Chemistry and Applications
ResumoAbstract The 2,2,2-trichloroethoxycarbonyl (Troc) group attached at the Nin function of tryptophan by acylation with Troc-Cl in the presence of a catalytic amount of tetra-n-butylammonium hydrogensulfate can be quantitatively removed either by cadmium dust in acetic acid or under basic conditions, e.g., hydrazine hydrate and NaOH, but is resistant to strong acidic conditions.
Referência(s)