The biochemistry of 2-deoxy-2-fluoro-dl-glyceraldehyde with a note on the toxicity of 2-deoxy-2-fluoroglycerol
1958; Elsevier BV; Volume: 1; Issue: 1 Linguagem: Inglês
10.1016/0006-2952(58)90003-0
ISSN1873-2968
AutoresR. D. O’Brien, Rudolph Peters,
Tópico(s)Eicosanoids and Hypertension Pharmacology
ResumoThe compound (FGA) is toxic to the mouse and rat, producing convulsions and accumulations of citrate, particularly in heart and kidney. It has little effect upon glycolysis, but is readily phosphorylated by glycerokinase. Evidence is presented that with kidney particles, some of the FGA is converted to fluoroacetate, some to a compound which can inhibit an enzyme acting somewhere between malate and citrate. In brain, FGA inhibits respiration in part by a non-specific aldehyde effect, in part by conversion to some other respiratory inhibitor. The toxicity of FGA is probably due to a conversion of at least a part of it to fluoroacetate. 2-Deoxy-2-fluoroglycerol was also found to be toxic to the mouse and to cause citrate accumulation.
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