Produção Nacional
Revisado por pares
Severe acute respiratory disease caused by pandemic influenza A H1N1 virus. A case series of hospitalized patients in Southeastern Brazil during the 2009 epidemic
2010; Elsevier BV; Volume: 14; Linguagem: Inglês
10.1016/j.ijid.2010.02.1720
ISSN1878-3511
AutoresAline Fiori dos Santos Feltrin, Kristopherson Lustosa Augusto, Jóni Costa Carvalho, J. Vitone, A. Silva, Joseph G. Morelli, F. Toniatti, MARIA EDUARDA ALVES REIS, Caroline Vitória Feitoza e Silva, B. Kemp, André Ricardo Ribas Freitas, M. Pacola, Rodrigo Nogueira Angerami,
Tópico(s)COVID-19 Clinical Research Studies
ResumoBackground: During the pandemic influenza A H1N1 (FluAH1N1) period in 2009, it was observed a significant number of suspected cases presenting severe acute respiratory disease (SARD). In this context, all health care settings have adapted their structure – including infection control strategies, emergency and intensive care unities organization, treatment protocols – to increase their capacity of pandemic response. The main objective of this study is to describe the main clinical and epidemiological features of a case serie of severe acute respiratory disease caused by pandemic FluAH1n1 in a metropolitan region. Methods: Retrospective and descriptive study based on information of medical records and epidemiological files of SARD hospitalized cases caused FluAH1N1 in 5 hospitals in the metropolitan region of Campinas, São Paulo State, during the first epidemic period in Brazil. Results: Between July/6 and October/30 there were evaluated 254 cases of SARD; of them, 49 have been confirmed as FluAH1N1 infection (19.3%) and 14 (5,5%) as seasonal influenza strain. Of the 49 confirmed FluAH1N1 cases, 28 were female (57.1%) and the median age was 26 years (range: 0-75 years). The median time from onset of illness and hospital admission was 2 days (range, 1 to 5). Nine cases (18.3%) were admitted in intensive care unity and 5 (10.2%) required mechanical ventilation. The most important clinical features were fever and cough(98%), dyspnoea (77.5%), and malaise (83.6%). X-ray abnormalities were present in 75.5% of patients; leucocytes count was elevated in 5 (10.2%) and reduced in 6 (12.2%) patients. Pre-existing conditions were observed in 28 patients (55.1%); chronic respiratory disease (51.8%) and obesity (22.2%) were the most frequent underlying medical conditions. There were 4 deaths associated with FluAH1N1 (lethality 8.1%), one of them with simultaneous seasonal influenza strain virus infection. Conclusion: As observed in other case series, it has been observed a higher frequency of SARD in female gender, younger adults, and in patients with underlying medical conditions. The identification of seasonal influenza virus strains in SARD patients reinforces the potential impact of seasonal influenza on morbidity and mortality annually and the importance of a continuous epidemiological and laboratorial surveillance of respiratory syndromes. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive
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