Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the knee
2005; BMJ; Volume: 10; Issue: 3 Linguagem: Inglês
10.1136/ebm.10.3.81
ISSN1473-6810
Autores Tópico(s)Dermatology and Skin Diseases
ResumoBookman AA, Williams KS, Shainhouse JZ. Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ 2004;171:333–8. [OpenUrl][1][Abstract/FREE Full Text][2] Q In patients with primary osteoarthritis (OA) of the knee, is a topical diclofenac (TD) solution more effective than topical vehicle control (VC) or placebo for providing symptom relief? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Rheumatology ★★★★★☆☆ Internal Medicine ★★★★★★★ ### ![Graphic][3] Design: randomised vehicle and placebo controlled trial. ### ![Graphic][4] Allocation: concealed.* ### ![Graphic][5] Blinding: blinded (patients, healthcare providers, data collectors, and outcome assessors).* ### ![Graphic][6] Follow up period: 28 days. ### ![Graphic][7] Setting: 7 medical centres in Ontario, Canada. ### ![Graphic][8] Patients: 248 patients who were 18–80 years of age (63% women, mean age 62 y) and had primary OA in ⩾1 knee (verified radiologically within the previous 6 mo) and at least moderate pain (identified with the Western Ontario and McMaster Universities [WOMAC] LK3.0 OA Index pain subscale). Exclusion criteria included secondary arthritis related to syphilitic … [1]: {openurl}?query=rft.jtitle%253DCanadian%2BMedical%2BAssociation%2BJournal%26rft.stitle%253DCMAJ%26rft.issn%253D0008-4409%26rft.aulast%253DBookman%26rft.auinit1%253DA.%2BA.M.%26rft.volume%253D171%26rft.issue%253D4%26rft.spage%253D333%26rft.epage%253D338%26rft.atitle%253DEffect%2Bof%2Ba%2Btopical%2Bdiclofenac%2Bsolution%2Bfor%2Brelieving%2Bsymptoms%2Bof%2Bprimary%2Bosteoarthritis%2Bof%2Bthe%2Bknee%253A%2Ba%2Brandomized%2Bcontrolled%2Btrial%26rft_id%253Dinfo%253Apmid%252F15313991%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=cmaj&resid=171/4/333&atom=%2Febmed%2F10%2F3%2F81.atom [3]: /embed/inline-graphic-1.gif [4]: /embed/inline-graphic-2.gif [5]: /embed/inline-graphic-3.gif [6]: /embed/inline-graphic-4.gif [7]: /embed/inline-graphic-5.gif [8]: /embed/inline-graphic-6.gif
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