The Questionable Role of Anti‐DNA Antibodies in the Pathogenesis of Systemic Lupus Erythematosus
1986; Wiley; Volume: 475; Issue: 1 Linguagem: Inglês
10.1111/j.1749-6632.1986.tb20872.x
ISSN1749-6632
AutoresJean‐François Bach, Laurent Jacob, G Feutren, François Tron,
Tópico(s)Chronic Lymphocytic Leukemia Research
ResumoAnnals of the New York Academy of SciencesVolume 475, Issue 1 p. 231-240 The Questionable Role of Anti-DNA Antibodies in the Pathogenesis of Systemic Lupus Erythematosus JEAN-FRANÇOIS BACH, JEAN-FRANÇOIS BACH Hopital Necker INSERM-CNRS 161 Rue de Sévres Paris 15, FranceSearch for more papers by this authorLAURENT JACOB, LAURENT JACOB Hopital Necker INSERM-CNRS 161 Rue de Sévres Paris 15, FranceSearch for more papers by this authorGILLES FEUTREN, GILLES FEUTREN Hopital Necker INSERM-CNRS 161 Rue de Sévres Paris 15, FranceSearch for more papers by this authorFRANÇOIS TRON, FRANÇOIS TRON Hopital Necker INSERM-CNRS 161 Rue de Sévres Paris 15, FranceSearch for more papers by this author JEAN-FRANÇOIS BACH, JEAN-FRANÇOIS BACH Hopital Necker INSERM-CNRS 161 Rue de Sévres Paris 15, FranceSearch for more papers by this authorLAURENT JACOB, LAURENT JACOB Hopital Necker INSERM-CNRS 161 Rue de Sévres Paris 15, FranceSearch for more papers by this authorGILLES FEUTREN, GILLES FEUTREN Hopital Necker INSERM-CNRS 161 Rue de Sévres Paris 15, FranceSearch for more papers by this authorFRANÇOIS TRON, FRANÇOIS TRON Hopital Necker INSERM-CNRS 161 Rue de Sévres Paris 15, FranceSearch for more papers by this author First published: July 1986 https://doi.org/10.1111/j.1749-6632.1986.tb20872.xCitations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Koffler, D., P. H. Shur & H. G. Kunkel. 1967. Immunologic studies concerning the nephritis of SLE. J. Exp. Med. 126: 607–624. 2 Koffler, D., V. Agnello & H. G. Kunkel. 1974. Polynucleotide immune complexes in serum and glomeruli of patients with systemic lupus erythematosus. Am. J. Pathol. 74: 109–124. 3 Krishnan, C. S. & M. H. Kaplan. 1967. Immunopathologic studies of systemic lupus erythematosus. II. Antinuclear reaction of globulin eluted from homogenates and isolated glomeruli of kidneys from patients with lupus nephritis. J. Clin. Invest. 46: 569–579. 4 Lambert, P. H. & F. J. Dixon. 1968. Pathogenesis of glomerulonephritis of NZB/W mice. J. Exp. Med. 127: 507–522. 5 Pincus, T., P. H. Schur, J. A. Rose, J. L. Decker & N. Talal. 1969. Measurement of serum DNA-binding activity in systemic lupus erythematosus. N. Engl. J. Med. 281: 701–705. 6 Tron, F. & J. F. Bach. 1977. Tests immunologiques pour le diagnostic du LED avant le traitement. Intérêt et limites. Nouv. Presse Med. 6: 2573–2578. 7 Hill, G. S., N. Hinglais, F. Tron & J. F. Bach. 1978. Systemic lupus erythematosus. Morphologic correlations with immunologic and clinical data at the time of biopsy. Am. J. Med. 64: 61–79. 8 Gershwin, M. E. & A. D. Steinberg. 1974. Qualitative characteristics of anti-DNA antibodies in lupus nephritis. Arthritis Rheum. 17: 947. 9 Leon, S. A., G. E. Green, E. Ehrlich, M. Poland & B. Shapiro. 1977. Avidity of antibodies in SLE. Relationship to severity of renal involvement. Arthritis Rheum. 20: 23–29. 10 Tron, F. & J. F. Bach. 1977. Relationships between antibodies to native DNA and glomerulonephritis in systemic lupus erythematosus. Clin. Exp. Immunol. 28: 426–432. 11 Taylor, R. P., D. Weber, A. V. Broccoli & J. B. Winfield. 1979. Stability of DNA-anti-DNA complexes. J. Immunol. 122: 115–120. 12 Huber, O., M. L. Greenberg & J. Huber. 1979. Complement-fixing anti-double-stranded DNA with the Crithidia method is a better indicator of active SLE than anti-DNA with the Farr method. J. Lab. Clin. Med. 93: 32–39. 13 Pennebaker, J. B., J. N. Gilliam & M. Ziff. 1977. Immunoglobulin classes of DNA binding activity in serum and skin in systemic lupus erythematosus. J. Clin. Invest. 60: 1331–1338. 14 Rothfield, N. F. & B. D. Stollar. 1967. The relation of immunoglobulin class, pattern of antinuclear antibody, and complement-fixing antibodies to DNA in sera from patients with systemic lupus erythematosus. J. Clin. Invest. 46: 1785–1794. 15 Winfield, J. B., I. Faiferman & D. Koffler. 1977. Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. J. Clin. Invest. 59: 90–96. 16 Talal, N., J. F. Roubinian, H. Shear, J. T. Hom & N. Miyasaka. 1980. Mechanisms of autoimmune disease. In Progress in Immunology. M. Fougereau & J. Dausset, Eds.: 889–905. Academic Press. New York . 17 Ebling, F. & B. H. Hahn. 1980. Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus: comparison of antibodies in serum and renal eluates. Arthritis Rheum. 23: 392–403. 18 Gavalchin, J., J. A. Nicklas, J. W. Eastcott, M. P. Madaio, B. D. Stollar, R. S. Schwartz & S. K. Datta. 1985. Lupus prone (SWR × NZB)F1 mice produce potentially nephritogenic autoantibodies inherited from the normal SWR parent. J. Immunol. 134: 885–894. 19 Feltkamp, T. E. W. 1975. The significance of the determination of DNA anti-DNA complexes. Scand. J. Rheum. 11: 33. 20 Izui, S., P. H. Lambert & P. A. Miescher. 1977. Failure to detect circulating DNA: Anti-DNA complexes in systemic lupus erythematosus. Clin. Exp. Immunol. 30: 388–392. 21 Cukier, R. & F. Tron. 1985. Monoclonal anti-DNA antibodies: an approach to studying SLE molecules. Clin. Exp. Immunol. 62: 143–149. 22 Izui, S., P. H. Lambert, H. Türler & P. A. Miescher. 1977. Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides. Identification of circulating DNA and renal localization of DNA anti-DNA complexes. J. Exp. Med. 145: 1115–1130. 23 Bruneau, C. & J. Benveniste. 1979. Circulating DNA: Anti-DNA complexes in systemic lupus erythematosus. Detection and characterization by ultracentrifugation. J. Clin. Invest. 64: 191–198. 24 Harbeck, R. J., E. J. Bardana, P. F. Kohler & R. I. Carr. 1973. DNA complexes: Their detection in systemic lupus erythematosus sera. J. Clin. Invest. 52: 789–795. 25 Tron, F., J. Letarte, M. C. Roque-Antunes Barreira & P. Lesavre. 1982. Specific detection of DNA-anti-DNA immune complexes in human SLE sera using murine monoclonal antibody. Clin. Exp. Immunol. 49: 481–487. 26 Cameron, J. S., M. H. Lessof, B. D. Williams & P. G. Williams. 1976. Disease activity in the nephritis of systemic lupus erythematosus in relation to serum complement concentrations. Clin. Exp. Immunol. 25: 418–427. 27 Tron, T., P. Jungers, D. Droz & J. F. Bach. 1980. Valeur des tests immunologiques dans la surveillance du traitement du lupus érythémateux disséminé. Nouv. Presse Med. 9: 2319–2323. 28 Lightfoot, R. W. & G. V. Hugues. 1976. Significance of persisting serologic abnormalities in SLE. Arthritis Rheum. 19: 837–843. 29 Israel-Biet, D., L. H. Noel, M. A. Bach, M. Dardenne & J. F. Bach. 1983. Marked reduction of DNA antibody production and glomerulopathy in thymulin (FTS-Zn) or cyclosporine A treated (NZB × NZW)F1 mice. Clin. Exp. Immunol. 54: 359–365. 30 Jones, M. G., G. Harris & G. Cowing. 1983. Response of murine autoimmune disease to cyclosporine and thiols. Transplant. Proc. 15(suppl. 1): 2904–2908. 31 Jacob, L. & F. Tron. 1982. Monoclonal anti-deoxyribonucleic antibodies. I. Isotype and specificity studies. J. Immunol. 128: 895–898. 32 Tron, F., L. Jacob & J. F. Bach. 1984. Binding of a murine monoclonal anti-DNA antibody to Raji cells. Implications for the interpretation of the Raji cell assay for immune complexes. Eur. J. Immunol. 14: 283–286. 33 Jacob, L., F. Tron, J. F. Bach & D. Louvard. 1984. A monoclonal anti-DNA antibody also binds to cell-surface protein(s). Proc. Natl. Acad. Sci. USA 81: 3843–3845. 34 Jacob, L., M. A. Lety, D. Louvard & J. F. Bach. 1985. Binding of a monoclonal anti-DNA autoantibody to identical protein(s) present at the surface of several human cell types involved in lupus pathogenesis. J. Clin. Invest. 75: 315–317. 35 Rubin, R. L., R. S. Balderas, E. M. Tan, F. J. Dixon & A. N. Theofilopoulos. 1984. Multiple autoantigen binding capabilities of mouse monoclonal antibodies selected for rheumatoid factor activity. J. Exp. Med. 159: 1429–1440. 36 Lafer, E. M., J. Rauch, C. Andrzejewski, Jr., D. Mudd, B. Furie, R. S. Schwartz & B. D. Stollar. 1981. Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids. J. Exp. Med. 153: 897–909. 37 Dighiero, G., P. Lemberi, J. C. Mazile, S. Rouyre, G. S. Butler-Browne, R. G. Whalen & S. Avrameas. 1983. Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens. J. Immunol. 131: 2267–2272. Citing Literature Volume475, Issue1Autoimmunity: Experimental and Clinical AspectsJuly 1986Pages 231-240 ReferencesRelatedInformation
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