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Mechanisms of Action of the Type-I Restriction Endonuclease, EcoB, and the recBC DNase from Escherichia coli

1979; Cold Spring Harbor Laboratory Press; Volume: 43; Linguagem: Inglês

10.1101/sqb.1979.043.01.114

1943-4456

John Rosamond, B Endlich, K. M. Telander, Stuart Linn,

Cancer therapeutics and mechanisms

We have been investigating two DNA-dependent ATPases from Escherichia coli, the type-I restriction endonuclease from E. coli B (EcoB) and exonuclease V (the recBC enzyme) of E. coli K12. This paper summarizes the results of our most recent studies of the mechanism of action of these enzymes in vitro and attempts to relate these mechanisms to in vivo functions.