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The Action of Physostigmine, Morphine, Cyclopentolate and Homatropine on the Secretion and Outflow of Aqueous Humour in the Rabbit Eye

1972; Wiley; Volume: 86; Issue: 2 Linguagem: Inglês

10.1111/j.1748-1716.1972.tb05329.x

1365-201X

Risto Uusitalo,

Ocular Surface and Contact Lens

Abstract The influence on the intraocular fluid dynamics (intraocular pressure, inflow and outflow) of one i.v. injection or a 3 day topical application of physostigmine, morphine, cyclopentolate or homatropine was investigated. Special attention was paid to the inflow of aqueous humour and ATPase activity in the ciliary body‐iris after administration of these drugs. Systemic injection of physostigmine caused a marked decrease in intraocular pressure, which seemed to be due to the decrease in inflow of aqueous humour. On the contrary, three day topical applications of this drug had no effect on the IOP or intraocular fluid dynamics. Intravenous injection of morphine increased both the inflow rate and the outflow facility of the eye. Cyclopentolate and homatropine did not decrease the outflow facility. However, cyclopentolate applied intravenously or topically increased both the inflow rate and the outflow facility slightly. Homatropine intravenously injected had no effect on the intraocular fluid dynamics but applied topically slightly increased the IOP, possibly due to the increased inflow of aqueous humour. None of these drugs caused any significant change in the NaK‐ATPase activity in the ciliary body‐iris. Physostigmine and morphine markedly reduced Mg‐ATPase activity. Physostigmine did not decrease Mg‐ATPase activity when the eye had been sympathectomized 7 days before administrations of the drug. It was concluded that the effect of physostigmine on Mg‐ATPase was possibly mediated by way of the sympathetic nervous system.