Expression and distribution of transcription factor NF-κB and inhibitor IκB in the inflamed peripheral nervous system
2001; Elsevier BV; Volume: 116; Issue: 2 Linguagem: Inglês
10.1016/s0165-5728(01)00306-x
ISSN1872-8421
AutoresBettina Andorfer, Bernd C. Kieseier, Emily K. Mathey, Patricia J. Armati, John D. Pollard, Nobuyuki Oka, Hans-Peter Hartung,
Tópico(s)Nerve injury and regeneration
ResumoThe NF-κB family of transcription factors is critically involved in the immune response. The activity of these proteins is under strict control of an inhibitory molecule called IκB. The present study investigated the expression and distribution pattern of NF-κB and IκB in sural nerve biopsies obtained from patients with Guillain–Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy, and various non-inflammatory neuropathies. In inflammatory demyelinating as well as non-inflammatory neuropathies, NF-κB was primarily expressed by macrophages, as determined by immunohistochemistry. IκB, however, could be localized to macrophages as well as T cells in inflammatory demyelinating neuropathies, whereas in non-inflammatory controls Schwann cells were found to be the primary cell type expressing this inhibitor. Quantitation of immunoreactivity revealed a statistically significant increase of NF-κB expression in inflammatory demyelinating cases compared to controls. Our results suggest an important function of the NF-κB pool in the genesis of inflammatory demyelination in the peripheral nervous system.
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